Assay Detail
Functional
CHEMBL853828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 LAI replication in MT2 cells by cytopathic effect assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.49 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.70 |
| CHEMBL218614 | — | — | 1 | 5.28 |
| CHEMBL384008 | — | — | 1 | - |
| CHEMBL384959 | — | — | 1 | - |
| CHEMBL425798 | — | — | 1 | - |
| CHEMBL217219 | — | — | 1 | - |
| CHEMBL384629 | — | — | 1 | - |
| CHEMBL383977 | — | — | 1 | - |
| CHEMBL386690 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL218614 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL384008 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL384959 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL425798 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL217219 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL384629 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL383977 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL386690 | — | EC50 | > | 10000.0 | nM | - |