Assay Detail
Functional
CHEMBL853860
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Inhibition of TNF-alpha-induced NF-kappaB activation in HEK293T cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.11 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218562 | — | — | 1 | 6.82 |
| CHEMBL83880 | — | — | 1 | 6.82 |
| CHEMBL214521 | — | — | 1 | 6.52 |
| CHEMBL215186 | — | — | 1 | 6.30 |
| CHEMBL215583 | — | — | 1 | 6.22 |
| CHEMBL215432 | — | — | 1 | 6.22 |
| CHEMBL214885 | — | — | 1 | 6.10 |
| CHEMBL383922 | — | — | 1 | 6.05 |
| CHEMBL218615 | — | — | 1 | 6.00 |
| CHEMBL215767 | — | — | 1 | 5.96 |
| CHEMBL215214 | — | — | 1 | 5.89 |
| CHEMBL215717 | — | — | 1 | 5.82 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218562 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL83880 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL214521 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL215186 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL215583 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL215432 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL214885 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL383922 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL218615 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL215767 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL215214 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL215717 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL165 | RESVERATROL | IC50 | = | 20000.0 | nM | 4.70 |