Compound Detail
CHEMBL215214
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL215214 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AXGWOAHWOMYXLE-ZHACJKMWSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
230.3
MW (Da)
5.01
ALogP
0
HBA
0
HBD
0.0
PSA (Ų)
0.54
QED
1
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| HEK-293T CHEMBL3706568 | IC50 | 5.89 | 5.89 | 1300.0 | 1 |
| Transcription factor p65 CHEMBL5533 | IC50 | 5.89 | 5.89 | 1300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| HEK-293T | IC50 | = | 1300.0 | nM | 5.89 | Inhibition of TNF-alpha-induced NF-kappaB activation in HEK293T cells | 17125270 |
| Transcription factor p65 | IC50 | = | 1300.0 | nM | 5.89 | Inhibition Assay: The actual target(s) whereby the most active substituted trans... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17125270 | 10.1021/jm060630x | HEK-293T | 2 |
| 17125270 | 10.1021/jm060630x | Radical scavenging activity | 2 |
Data from ChEMBL 36 via Core Engine