Assay Detail
Binding
CHEMBL854142
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Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase involving magnesium chelation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.76 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175882 | — | — | 1 | 6.82 |
| CHEMBL382170 | — | — | 1 | 6.17 |
| CHEMBL382383 | — | — | 1 | 6.12 |
| CHEMBL203575 | — | — | 1 | 5.92 |
| CHEMBL181653 | — | — | 1 | 5.58 |
| CHEMBL205026 | — | — | 1 | 5.54 |
| CHEMBL366051 | — | — | 1 | 5.38 |
| CHEMBL440562 | — | — | 1 | 4.52 |
| CHEMBL203976 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175882 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL382170 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL382383 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL203575 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL181653 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL205026 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL366051 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL440562 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL203976 | — | IC50 | > | 50000.0 | nM | - |