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Assay Detail

CHEMBL854189

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Functional
Activity at TP receptor assessed as inhibition of U46619-induced platelet aggregation in platelet rich plasma
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Tissue Plasma
Confidence 9 — Direct single protein target
Curated By Expert

Target

Thromboxane A2 receptor (CHEMBL2069)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of an indole series of prostaglandin D2 receptor antagonists.
Sturino CF, Lachance N, Boyd M, Berthelette C, Labelle M, Li L, Roy B, Scheigetz J, Tsou N, Brideau C, Cauchon E, Carriere MC, Denis D, Greig G, Kargman S, Lamontagne S, Mathieu MC, Sawyer N, Slipetz D, O'Neill G, Wang Z, Zamboni R, Metters KM, Young RN.
Bioorg Med Chem Lett (2006) 16 : 3043 -3048
PubMed 16529930 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 4.73 5.08

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL383484 1 5.08
CHEMBL207203 1 4.37

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL383484 IC50 = 8400.0 nM 5.08
CHEMBL207203 IC50 = 43000.0 nM 4.37