Assay Detail
Binding
CHEMBL854196
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]IMPY from beta amyloid in human AD cortical tissue
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of two 18F-labeled imidazo[1,2-a]pyridine analogues as potential agents for imaging beta-amyloid in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.54 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207456 | PITTSBURGH COMPOUND B | 2.0 | 1 | 8.11 |
| CHEMBL78012 | — | — | 1 | 7.99 |
| CHEMBL382407 | — | — | 1 | 7.32 |
| CHEMBL381708 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207456 | PITTSBURGH COMPOUND B | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL78012 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL382407 | — | Ki | = | 48.3 | nM | 7.32 |
| CHEMBL381708 | — | Ki | = | 177.0 | nM | 6.75 |