Assay Detail
Binding
CHEMBL854221
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Inhibition of PTP1B
29
Total Activities
29
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 5.94 | 6.85 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215335 | — | — | 1 | 6.85 |
| CHEMBL383882 | — | — | 1 | 6.70 |
| CHEMBL214912 | — | — | 1 | 6.60 |
| CHEMBL214502 | — | — | 1 | 6.52 |
| CHEMBL386616 | — | — | 1 | 6.44 |
| CHEMBL214911 | — | — | 1 | 6.30 |
| CHEMBL383967 | — | — | 1 | 6.24 |
| CHEMBL212232 | — | — | 1 | 6.22 |
| CHEMBL387242 | — | — | 1 | 6.21 |
| CHEMBL214794 | — | — | 1 | 6.13 |
| CHEMBL214378 | — | — | 1 | 6.09 |
| CHEMBL385276 | — | — | 1 | 6.00 |
| CHEMBL213662 | — | — | 1 | 6.00 |
| CHEMBL438089 | — | — | 1 | 5.92 |
| CHEMBL373883 | — | — | 1 | 5.85 |
| CHEMBL212335 | — | — | 1 | 5.80 |
| CHEMBL212285 | — | — | 1 | 5.60 |
| CHEMBL385896 | — | — | 1 | 5.52 |
| CHEMBL213758 | — | — | 1 | 5.50 |
| CHEMBL215242 | — | — | 1 | 5.48 |
| CHEMBL215656 | — | — | 1 | 5.40 |
| CHEMBL215243 | — | — | 1 | 5.30 |
| CHEMBL379196 | — | — | 1 | 5.05 |
| CHEMBL373413 | — | — | 1 | 4.75 |
| CHEMBL212605 | — | — | 1 | - |
| CHEMBL445320 | — | — | 1 | - |
| CHEMBL214736 | — | — | 1 | - |
| CHEMBL212289 | — | — | 1 | - |
| CHEMBL212296 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215335 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL383882 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL214912 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL214502 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL386616 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL214911 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL383967 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL212232 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL387242 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL214794 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL214378 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL385276 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL213662 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL438089 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL373883 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL212335 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL212285 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL385896 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL213758 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL215242 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL215656 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL215243 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL379196 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL373413 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL212605 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL445320 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL214736 | — | Activity | - | — | - | |
| CHEMBL212289 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL212296 | — | Ki | = | 160000.0 | nM | - |