Assay Detail
Binding
CHEMBL854225
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TCPTP
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Tyrosine-protein phosphatase non-receptor type 2 (CHEMBL3807) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.36 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215335 | — | — | 1 | 6.75 |
| CHEMBL213758 | — | — | 1 | 6.50 |
| CHEMBL214378 | — | — | 1 | 6.17 |
| CHEMBL379196 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215335 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL213758 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL214378 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL379196 | — | Ki | = | 1000.0 | nM | 6.00 |