Assay Detail
Binding
CHEMBL854312
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Inhibition of porcine brain tubulin polymerization by GTP-induced assembly
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.24 | 5.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 5.81 |
| CHEMBL372120 | — | — | 1 | 5.35 |
| CHEMBL382519 | — | — | 1 | 5.04 |
| CHEMBL196754 | — | — | 1 | 4.75 |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | - |
| CHEMBL381416 | — | — | 1 | - |
| CHEMBL378162 | — | — | 1 | - |
| CHEMBL103307 | — | — | 1 | - |
| CHEMBL382323 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL372120 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL382519 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL196754 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL276711 | SEMAXANIB | IC50 | > | 40000.0 | nM | - |
| CHEMBL381416 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL378162 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL103307 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL382323 | — | IC50 | > | 40000.0 | nM | - |