Assay Detail
Functional
CHEMBL854437
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against NTR expressing chinese hamster V79 cells after 72 hrs
11
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | V79 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.20 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144896 | — | — | 1 | 9.40 |
| CHEMBL375660 | — | — | 2 | 7.57 |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | 7.44 |
| CHEMBL61511 | PERFOSFAMIDE | 2.0 | 1 | 5.57 |
| CHEMBL209962 | — | — | 2 | 5.34 |
| CHEMBL213994 | — | — | 2 | 4.34 |
| CHEMBL377628 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144896 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL375660 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL375660 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL23330 | TRETAZICAR | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL61511 | PERFOSFAMIDE | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL209962 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL213994 | — | IC50 | = | 45300.0 | nM | 4.34 |
| CHEMBL209962 | — | IC50 | = | 48300.0 | nM | 4.32 |
| CHEMBL213994 | — | IC50 | = | 51500.0 | nM | 4.29 |
| CHEMBL377628 | — | IC50 | - | — | - | |
| CHEMBL377628 | — | IC50 | - | — | - |