Assay Detail
Functional
CHEMBL854443
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against NTR expressing chinese hamster V79 cells after 1 hr
10
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | V79 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.94 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144896 | — | — | 1 | 8.00 |
| CHEMBL375660 | — | — | 2 | 6.77 |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | 6.51 |
| CHEMBL377628 | — | — | 2 | - |
| CHEMBL209962 | — | — | 2 | - |
| CHEMBL213994 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144896 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL375660 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL23330 | TRETAZICAR | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL375660 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL377628 | — | IC50 | - | — | - | |
| CHEMBL209962 | — | IC50 | - | — | - | |
| CHEMBL209962 | — | IC50 | - | — | - | |
| CHEMBL377628 | — | IC50 | - | — | - | |
| CHEMBL213994 | — | IC50 | - | — | - | |
| CHEMBL213994 | — | IC50 | - | — | - |