Assay Detail
Binding
CHEMBL854613
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Inhibition of tyrosinase
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Chemical transformations of oxyresveratrol (trans-2,4,3',5'-tetrahydroxystilbene) into a potent tyrosinase inhibitor and a strong cytotoxic agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.35 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221291 | — | — | 1 | 5.80 |
| CHEMBL43065 | OXYRESVERATROL | — | 1 | 4.90 |
| CHEMBL287556 | KOJIC ACID | — | 1 | - |
| CHEMBL222164 | — | — | 1 | - |
| CHEMBL221300 | — | — | 1 | - |
| CHEMBL46909 | — | — | 1 | - |
| CHEMBL218269 | — | — | 1 | - |
| CHEMBL219219 | — | — | 1 | - |
| CHEMBL219050 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221291 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL43065 | OXYRESVERATROL | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 133400.0 | nM | - |
| CHEMBL222164 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL221300 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL46909 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL218269 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL219219 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL219050 | — | IC50 | > | 100000.0 | nM | - |