Assay Detail
Binding
CHEMBL854908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 125I-MCH from MCH-R1 expressed in IMR-32 cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An evaluation of 3,4-methylenedioxy phenyl replacements in the aminopiperidine chromone class of MCHr1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.53 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386281 | — | — | 1 | 9.00 |
| CHEMBL266725 | — | — | 1 | 8.52 |
| CHEMBL214021 | — | — | 1 | 8.52 |
| CHEMBL216104 | — | — | 1 | 8.40 |
| CHEMBL274168 | — | — | 1 | 8.30 |
| CHEMBL216554 | — | — | 1 | 8.15 |
| CHEMBL216482 | — | — | 1 | 8.15 |
| CHEMBL216524 | — | — | 1 | 8.00 |
| CHEMBL217233 | — | — | 1 | 7.72 |
| CHEMBL216180 | — | — | 1 | 7.42 |
| CHEMBL217435 | — | — | 1 | 7.37 |
| CHEMBL269352 | — | — | 1 | 7.33 |
| CHEMBL384043 | — | — | 1 | 7.02 |
| CHEMBL384844 | — | — | 1 | 6.78 |
| CHEMBL215457 | — | — | 1 | 5.90 |
| CHEMBL216680 | — | — | 1 | 5.77 |
| CHEMBL216323 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386281 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL266725 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL214021 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL216104 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL274168 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL216554 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL216482 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL216524 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL217233 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL216180 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL217435 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL269352 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL384043 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL384844 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL215457 | — | IC50 | = | 1267.0 | nM | 5.90 |
| CHEMBL216680 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL216323 | — | IC50 | = | 2010.0 | nM | 5.70 |