Compound Detail
CHEMBL216680
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Basic Information
| ChEMBL ID | CHEMBL216680 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AXOYDNAEBFRXFX-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
437.5
MW (Da)
3.28
ALogP
5
HBA
2
HBD
91.7
PSA (Ų)
0.64
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 7.32 | 5.82 | 47.7 | 2 |
| Melanin-concentrating hormone receptor 1 CHEMBL344 | IC50 | 5.77 | 5.77 | 1690.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 47.7 | nM | 7.32 | Displacement of [3H]dofetilide from hERG | 17064075 |
| Melanin-concentrating hormone receptor 1 | IC50 | = | 1690.0 | nM | 5.77 | Displacement of [125I]MCH from MCHr1 expressed in IMR32 cells | 17064075 |
| Melanin-concentrating hormone receptor 1 | IC50 | = | 1700.0 | nM | 5.77 | Displacement of 125I-MCH from MCH-R1 expressed in IMR-32 cells | 17234405 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 47700.0 | nM | 4.32 | Displacement of 3H-dofetilide from hERG-expressing HEK membrane homogenates | 17234405 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17064075 | 10.1021/jm060683e | Melanin-concentrating hormone receptor 1 | 2 |
| 17064075 | 10.1021/jm060683e | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 17234405 | 10.1016/j.bmcl.2006.11.065 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 17234405 | 10.1016/j.bmcl.2006.11.065 | Melanin-concentrating hormone receptor 1 | 1 |
| 17234405 | 10.1016/j.bmcl.2006.11.065 | Melanin-concentrating hormone receptor | 1 |
Data from ChEMBL 36 via Core Engine