Assay Detail
Binding
CHEMBL909940
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]dofetilide from hERG
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 8.03 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204828 | — | — | 1 | 8.85 |
| CHEMBL217706 | — | — | 1 | 8.60 |
| CHEMBL217789 | — | — | 1 | 8.44 |
| CHEMBL213715 | — | — | 1 | 8.44 |
| CHEMBL214731 | — | — | 1 | 8.40 |
| CHEMBL387417 | — | — | 1 | 8.30 |
| CHEMBL217593 | — | — | 1 | 8.27 |
| CHEMBL217707 | — | — | 1 | 8.25 |
| CHEMBL387178 | — | — | 1 | 8.21 |
| CHEMBL214767 | — | — | 1 | 8.17 |
| CHEMBL214377 | — | — | 1 | 8.13 |
| CHEMBL214768 | — | — | 1 | 8.07 |
| CHEMBL217400 | — | — | 1 | 7.98 |
| CHEMBL387418 | — | — | 1 | 7.98 |
| CHEMBL206081 | — | — | 1 | 7.94 |
| CHEMBL425448 | — | — | 1 | 7.91 |
| CHEMBL217105 | — | — | 1 | 7.87 |
| CHEMBL387309 | — | — | 1 | 7.83 |
| CHEMBL214021 | — | — | 1 | 7.82 |
| CHEMBL217442 | — | — | 1 | 7.80 |
| CHEMBL213761 | — | — | 1 | 7.70 |
| CHEMBL384487 | — | — | 1 | 7.69 |
| CHEMBL216225 | — | — | 1 | 7.67 |
| CHEMBL216680 | — | — | 1 | 7.32 |
| CHEMBL215631 | — | — | 1 | 7.20 |
| CHEMBL214278 | — | — | 1 | - |
| CHEMBL214075 | — | — | 1 | - |
| CHEMBL214679 | — | — | 1 | - |
| CHEMBL214413 | — | — | 1 | - |
| CHEMBL402868 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204828 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL217706 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL213715 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL217789 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL214731 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL387417 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL217593 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL217707 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL387178 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL214767 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL214377 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL214768 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL217400 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL387418 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL206081 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL425448 | — | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL217105 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL387309 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL214021 | — | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL217442 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL213761 | — | IC50 | = | 19.9 | nM | 7.70 |
| CHEMBL384487 | — | IC50 | = | 20.3 | nM | 7.69 |
| CHEMBL216225 | — | IC50 | = | 21.2 | nM | 7.67 |
| CHEMBL216680 | — | IC50 | = | 47.7 | nM | 7.32 |
| CHEMBL215631 | — | IC50 | = | 63.7 | nM | 7.20 |
| CHEMBL2113245 | — | IC50 | - | — | - | |
| CHEMBL441542 | — | IC50 | - | — | - | |
| CHEMBL277531 | — | IC50 | - | — | - | |
| CHEMBL386021 | — | IC50 | - | — | - | |
| CHEMBL216777 | — | IC50 | - | — | - | |
| CHEMBL387219 | — | IC50 | - | — | - | |
| CHEMBL213658 | — | IC50 | - | — | - | |
| CHEMBL217925 | — | IC50 | - | — | - | |
| CHEMBL216577 | — | IC50 | - | — | - | |
| CHEMBL216133 | — | IC50 | - | — | - | |
| CHEMBL402868 | — | IC50 | - | — | - | |
| CHEMBL214413 | — | IC50 | - | — | - | |
| CHEMBL214679 | — | IC50 | - | — | - | |
| CHEMBL214075 | — | IC50 | - | — | - | |
| CHEMBL214278 | — | IC50 | - | — | - |