Assay Detail
Functional
CHEMBL855011
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human DND1 cells after 72 hrs
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DND1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of carbazole sulfonamides as a novel class of antimitotic agents against solid tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.34 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.60 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.92 |
| CHEMBL216767 | — | — | 1 | 7.16 |
| CHEMBL216879 | — | — | 1 | 7.05 |
| CHEMBL437336 | — | — | 1 | 7.05 |
| CHEMBL385606 | — | — | 1 | 6.92 |
| CHEMBL216846 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL61 | PODOFILOX | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL216767 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL216879 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL437336 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL385606 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL216846 | — | IC50 | = | 195.0 | nM | 6.71 |