Assay Detail
Functional
CHEMBL855034
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at CB1 receptor assessed as stimulation of [35S]GTP-gamma-S binding in DBA/J2 mouse brain
5
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.04 | 7.57 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216382 | — | — | 2 | 7.57 |
| CHEMBL217549 | — | — | 2 | 6.86 |
| CHEMBL188 | WIN-552122 | — | 1 | 6.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216382 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL217549 | — | EC50 | = | 138.0 | nM | 6.86 |
| CHEMBL188 | WIN-552122 | EC50 | = | 204.0 | nM | 6.69 |
| CHEMBL216382 | — | Activity | - | — | - | |
| CHEMBL217549 | — | Activity | - | — | - |