Assay Detail
Binding
CHEMBL855069
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Inhibition of human ACAT1 expressed in Hi5 cells
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BTI-TN-5B1-4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.50 | 6.85 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15611 | OLEIC ACID ANILIDE | — | 1 | 6.85 |
| CHEMBL200429 | CUDRAXANTHONE C | — | 1 | 4.70 |
| CHEMBL440392 | — | — | 1 | 4.40 |
| CHEMBL371024 | CUDRAXANTHONE M | — | 1 | 4.25 |
| CHEMBL425926 | CUDRAXANTHONE D | — | 1 | 4.24 |
| CHEMBL218550 | — | — | 1 | 4.23 |
| CHEMBL197916 | CUDRAXANTHONE L | — | 1 | 4.17 |
| CHEMBL220746 | CUDRAFLAVANONE A | — | 1 | 4.08 |
| CHEMBL218383 | — | — | 1 | 4.05 |
| CHEMBL370126 | MACLURAXANTHONE B | — | 1 | 4.02 |
| CHEMBL221908 | — | — | 1 | - |
| CHEMBL221907 | CUDRAFLAVONE B | — | 1 | - |
| CHEMBL218741 | — | — | 1 | - |
| CHEMBL199304 | ISOCUDRANIAXANTHONE B | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15611 | OLEIC ACID ANILIDE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL200429 | CUDRAXANTHONE C | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL440392 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL371024 | CUDRAXANTHONE M | IC50 | = | 56800.0 | nM | 4.25 |
| CHEMBL425926 | CUDRAXANTHONE D | IC50 | = | 57600.0 | nM | 4.24 |
| CHEMBL218550 | — | IC50 | = | 59200.0 | nM | 4.23 |
| CHEMBL197916 | CUDRAXANTHONE L | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL220746 | CUDRAFLAVANONE A | IC50 | = | 82400.0 | nM | 4.08 |
| CHEMBL218383 | — | IC50 | = | 89600.0 | nM | 4.05 |
| CHEMBL370126 | MACLURAXANTHONE B | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL221908 | — | Activity | - | — | - | |
| CHEMBL221907 | CUDRAFLAVONE B | Activity | - | — | - | |
| CHEMBL218741 | — | Activity | - | — | - | |
| CHEMBL199304 | ISOCUDRANIAXANTHONE B | IC50 | = | 148000.0 | nM | - |