Assay Detail
Binding
CHEMBL855089
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DAT
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: synthesis and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 6.51 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218997 | — | — | 2 | 8.00 |
| CHEMBL220766 | — | — | 1 | 7.51 |
| CHEMBL218581 | — | — | 1 | 7.50 |
| CHEMBL218174 | — | — | 1 | 7.02 |
| CHEMBL217987 | — | — | 1 | 6.92 |
| CHEMBL386073 | — | — | 1 | 6.80 |
| CHEMBL219048 | — | — | 1 | 6.66 |
| CHEMBL220819 | — | — | 1 | 6.60 |
| CHEMBL218262 | — | — | 1 | 6.53 |
| CHEMBL218568 | — | — | 1 | 6.35 |
| CHEMBL384199 | — | — | 1 | 6.21 |
| CHEMBL220765 | — | — | 1 | 6.21 |
| CHEMBL220713 | — | — | 1 | 6.19 |
| CHEMBL376737 | — | — | 1 | 6.12 |
| CHEMBL221067 | — | — | 1 | 6.12 |
| CHEMBL221903 | — | — | 1 | 6.07 |
| CHEMBL386493 | — | — | 1 | 6.03 |
| CHEMBL383879 | — | — | 1 | 5.91 |
| CHEMBL384649 | — | — | 1 | 5.68 |
| CHEMBL220801 | — | — | 1 | 5.65 |
| CHEMBL385607 | — | — | 1 | 5.58 |
| CHEMBL217928 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218997 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL220766 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL218581 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL218997 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL218174 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL217987 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL386073 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL219048 | — | Ki | = | 219.0 | nM | 6.66 |
| CHEMBL220819 | — | Ki | = | 251.0 | nM | 6.60 |
| CHEMBL218262 | — | Ki | = | 297.0 | nM | 6.53 |
| CHEMBL218568 | — | Ki | = | 451.0 | nM | 6.35 |
| CHEMBL384199 | — | Ki | = | 609.0 | nM | 6.21 |
| CHEMBL220765 | — | Ki | = | 621.0 | nM | 6.21 |
| CHEMBL220713 | — | Ki | = | 651.0 | nM | 6.19 |
| CHEMBL376737 | — | Ki | = | 754.0 | nM | 6.12 |
| CHEMBL221067 | — | Ki | = | 756.0 | nM | 6.12 |
| CHEMBL221903 | — | Ki | = | 855.0 | nM | 6.07 |
| CHEMBL386493 | — | Ki | = | 931.0 | nM | 6.03 |
| CHEMBL383879 | — | Ki | = | 1224.0 | nM | 5.91 |
| CHEMBL384649 | — | Ki | = | 2082.0 | nM | 5.68 |
| CHEMBL220801 | — | Ki | = | 2240.0 | nM | 5.65 |
| CHEMBL385607 | — | Ki | = | 2659.0 | nM | 5.58 |
| CHEMBL217928 | — | Ki | - | — | - |