Assay Detail
Binding
CHEMBL855090
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NET
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: synthesis and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 6.22 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218997 | — | — | 2 | 7.43 |
| CHEMBL218581 | — | — | 1 | 7.41 |
| CHEMBL217987 | — | — | 1 | 7.02 |
| CHEMBL219048 | — | — | 1 | 6.63 |
| CHEMBL218174 | — | — | 1 | 6.59 |
| CHEMBL220713 | — | — | 1 | 6.50 |
| CHEMBL376737 | — | — | 1 | 6.42 |
| CHEMBL220766 | — | — | 1 | 6.41 |
| CHEMBL384199 | — | — | 1 | 6.30 |
| CHEMBL220765 | — | — | 1 | 6.28 |
| CHEMBL218262 | — | — | 1 | 6.06 |
| CHEMBL386493 | — | — | 1 | 5.98 |
| CHEMBL221903 | — | — | 1 | 5.91 |
| CHEMBL218568 | — | — | 1 | 5.86 |
| CHEMBL383879 | — | — | 1 | 5.86 |
| CHEMBL386073 | — | — | 1 | 5.83 |
| CHEMBL220801 | — | — | 1 | 5.74 |
| CHEMBL220819 | — | — | 1 | 5.46 |
| CHEMBL221067 | — | — | 1 | 5.38 |
| CHEMBL385607 | — | — | 1 | 5.30 |
| CHEMBL384649 | — | — | 1 | 5.03 |
| CHEMBL217928 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218997 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL218581 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL218997 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL217987 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL219048 | — | Ki | = | 233.0 | nM | 6.63 |
| CHEMBL218174 | — | Ki | = | 257.0 | nM | 6.59 |
| CHEMBL220713 | — | Ki | = | 317.0 | nM | 6.50 |
| CHEMBL376737 | — | Ki | = | 381.0 | nM | 6.42 |
| CHEMBL220766 | — | Ki | = | 388.0 | nM | 6.41 |
| CHEMBL384199 | — | Ki | = | 497.0 | nM | 6.30 |
| CHEMBL220765 | — | Ki | = | 524.0 | nM | 6.28 |
| CHEMBL218262 | — | Ki | = | 876.0 | nM | 6.06 |
| CHEMBL386493 | — | Ki | = | 1052.0 | nM | 5.98 |
| CHEMBL221903 | — | Ki | = | 1230.0 | nM | 5.91 |
| CHEMBL218568 | — | Ki | = | 1390.0 | nM | 5.86 |
| CHEMBL383879 | — | Ki | = | 1379.0 | nM | 5.86 |
| CHEMBL386073 | — | Ki | = | 1480.0 | nM | 5.83 |
| CHEMBL220801 | — | Ki | = | 1820.0 | nM | 5.74 |
| CHEMBL220819 | — | Ki | = | 3449.0 | nM | 5.46 |
| CHEMBL221067 | — | Ki | = | 4168.0 | nM | 5.38 |
| CHEMBL385607 | — | Ki | = | 5007.0 | nM | 5.30 |
| CHEMBL384649 | — | Ki | = | 9261.0 | nM | 5.03 |
| CHEMBL217928 | — | Ki | - | — | - |