Assay Detail
Functional
CHEMBL855091
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Inhibition of eotaxin-induced calcium mobilization in eosinophil
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Eosinophil |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: synthesis and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.79 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386073 | — | — | 1 | 8.92 |
| CHEMBL221067 | — | — | 1 | 7.58 |
| CHEMBL383879 | — | — | 1 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386073 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL221067 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL383879 | — | IC50 | = | 133.0 | nM | 6.88 |