Assay Detail
Functional
CHEMBL855092
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Inhibition of eotaxin-induced human eosinophil chemotaxis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Eosinophil |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: synthesis and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.03 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386073 | — | — | 1 | 8.33 |
| CHEMBL221067 | — | — | 1 | 7.72 |
| CHEMBL383879 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386073 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL221067 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL383879 | — | EC50 | > | 100.0 | nM | - |