Assay Detail
Binding
CHEMBL855268
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and receptor binding properties of chimeric peptides containing a mu-opioid receptor ligand and nociceptin/orphanin FQ receptor ligand Ac-RYYRIK-amide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.38 | 10.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441930 | — | — | 1 | 10.32 |
| CHEMBL404792 | — | — | 1 | 9.82 |
| CHEMBL278789 | DERMORPHIN | — | 1 | 9.27 |
| CHEMBL215513 | — | — | 1 | 8.93 |
| CHEMBL412939 | — | — | 1 | 8.56 |
| CHEMBL437723 | — | — | 1 | - |
| CHEMBL414736 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441930 | — | IC50 | = | 0.0477 | nM | 10.32 |
| CHEMBL404792 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL278789 | DERMORPHIN | IC50 | = | 0.538 | nM | 9.27 |
| CHEMBL215513 | — | IC50 | = | 1.18 | nM | 8.93 |
| CHEMBL412939 | — | IC50 | = | 2.76 | nM | 8.56 |
| CHEMBL437723 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL414736 | — | IC50 | = | 0.00236 | nM | - |