Assay Detail
Binding
CHEMBL855414
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human M3 receptor assessed as inhibition of carbachol binding
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of novel derivatives of the muscarinic agonist tetra(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether (CDD-0304): effects of structural modifications on the binding and activity at muscarinic receptor subtypes and chimeras.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.93 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386983 | — | — | 1 | 7.20 |
| CHEMBL216927 | — | — | 1 | 6.80 |
| CHEMBL216928 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386983 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL216927 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL216928 | — | Kd | = | 158.49 | nM | 6.80 |