Assay Detail
Functional
CHEMBL855664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of human VEGF in HEK293 cells
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of a series of novel pyrazolopyridines as HIF-1alpha prolyl hydroxylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.42 | 6.00 |
| Activity | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222114 | — | — | 1 | 6.00 |
| CHEMBL221189 | — | — | 1 | 5.60 |
| CHEMBL221013 | — | — | 1 | 5.42 |
| CHEMBL221012 | — | — | 1 | 5.13 |
| CHEMBL386421 | — | — | 1 | 4.96 |
| CHEMBL222115 | — | — | 1 | - |
| CHEMBL374147 | — | — | 1 | - |
| CHEMBL221241 | — | — | 1 | - |
| CHEMBL218424 | — | — | 1 | - |
| CHEMBL218070 | — | — | 1 | - |
| CHEMBL269093 | — | — | 1 | - |
| CHEMBL375008 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222114 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL221189 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL221013 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL221012 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL386421 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL222115 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL374147 | — | Activity | - | — | - | |
| CHEMBL221241 | — | Activity | - | — | - | |
| CHEMBL218424 | — | Activity | - | — | - | |
| CHEMBL218070 | — | Activity | - | — | - | |
| CHEMBL269093 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL375008 | — | Activity | - | — | - |