Assay Detail
ADMET
CHEMBL855677
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Cytotoxicity against human NCI-H187 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | NCI-H187 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Chemical transformations of oxyresveratrol (trans-2,4,3',5'-tetrahydroxystilbene) into a potent tyrosinase inhibitor and a strong cytotoxic agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.63 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.00 |
| CHEMBL221300 | — | — | 1 | 6.52 |
| CHEMBL123 | ELLIPTECINE | — | 1 | 5.72 |
| CHEMBL46909 | — | — | 1 | 5.10 |
| CHEMBL219219 | — | — | 1 | 4.96 |
| CHEMBL218269 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL221300 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL123 | ELLIPTECINE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL46909 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL219219 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL218269 | — | IC50 | = | 33500.0 | nM | 4.47 |