Assay Detail
Functional
CHEMBL855751
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist potency on BK-induced contraction of guinea pig ileum longitudinal smooth muscle
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of novel sulfonamide-containing bradykinin hB2 receptor antagonists. 2. Synthesis and structure-activity relationships of alpha,alpha-cycloalkylglycine sulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 9.93 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220596 | — | — | 1 | 10.40 |
| CHEMBL375689 | — | — | 1 | 10.00 |
| CHEMBL375820 | — | — | 1 | 10.00 |
| CHEMBL205093 | — | — | 1 | 10.00 |
| CHEMBL380273 | — | — | 1 | 10.00 |
| CHEMBL220595 | — | — | 1 | 9.80 |
| CHEMBL383167 | — | — | 1 | 9.70 |
| CHEMBL207939 | — | — | 1 | 9.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220596 | — | Kd | = | 0.03981 | nM | 10.40 |
| CHEMBL375689 | — | Kd | = | 0.1 | nM | 10.00 |
| CHEMBL375820 | — | Kd | = | 0.1 | nM | 10.00 |
| CHEMBL205093 | — | Kd | = | 0.1 | nM | 10.00 |
| CHEMBL380273 | — | Kd | = | 0.1 | nM | 10.00 |
| CHEMBL220595 | — | Kd | = | 0.1585 | nM | 9.80 |
| CHEMBL383167 | — | Kd | = | 0.1995 | nM | 9.70 |
| CHEMBL207939 | — | Kd | = | 0.3162 | nM | 9.50 |