Assay Detail
Binding
CHEMBL855824
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human f10a
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 9.30 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214462 | — | — | 1 | 9.96 |
| CHEMBL438647 | — | — | 1 | 9.77 |
| CHEMBL385487 | — | — | 1 | 9.74 |
| CHEMBL558198 | RAZAXABAN HYDROCHLORIDE | -1.0 | 1 | 9.72 |
| CHEMBL384129 | — | — | 1 | 9.68 |
| CHEMBL215158 | — | — | 1 | 9.66 |
| CHEMBL212770 | — | — | 1 | 9.60 |
| CHEMBL213865 | — | — | 1 | 9.57 |
| CHEMBL384140 | — | — | 1 | 9.46 |
| CHEMBL385198 | — | — | 1 | 9.46 |
| CHEMBL215426 | — | — | 1 | 9.46 |
| CHEMBL386463 | — | — | 1 | 9.43 |
| CHEMBL214444 | — | — | 1 | 9.30 |
| CHEMBL386203 | — | — | 1 | 9.30 |
| CHEMBL386101 | — | — | 1 | 9.28 |
| CHEMBL214730 | — | — | 1 | 9.11 |
| CHEMBL214550 | — | — | 1 | 8.89 |
| CHEMBL386246 | — | — | 1 | 8.82 |
| CHEMBL387408 | — | — | 1 | 8.80 |
| CHEMBL217655 | — | — | 1 | 8.77 |
| CHEMBL387481 | — | — | 1 | 8.49 |
| CHEMBL218131 | — | — | 1 | 8.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214462 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL438647 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL385487 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL558198 | RAZAXABAN HYDROCHLORIDE | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL384129 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL215158 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL212770 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL213865 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL384140 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL385198 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL215426 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL386463 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL214444 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL386203 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL386101 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL214730 | — | Ki | = | 0.77 | nM | 9.11 |
| CHEMBL214550 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL386246 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL387408 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL217655 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL387481 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL218131 | — | Ki | = | 5.5 | nM | 8.26 |