Assay Detail
Binding
CHEMBL855830
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human activated protein C
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 4.72 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL213865 | — | — | 1 | 4.72 |
| CHEMBL558198 | RAZAXABAN HYDROCHLORIDE | -1.0 | 1 | 4.71 |
| CHEMBL386463 | — | — | 1 | - |
| CHEMBL438647 | — | — | 1 | - |
| CHEMBL384129 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL213865 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL558198 | RAZAXABAN HYDROCHLORIDE | Ki | = | 19700.0 | nM | 4.71 |
| CHEMBL386463 | — | Ki | > | 76000.0 | nM | - |
| CHEMBL438647 | — | Ki | > | 37000.0 | nM | - |
| CHEMBL384129 | — | Ki | > | 20000.0 | nM | - |