Assay Detail
Functional
CHEMBL855867
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Antiproliferative activity against mouse NIH3T3 cell line
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and anti-angiogenesis activity of coumarin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.95 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.89 |
| CHEMBL210065 | — | — | 1 | 5.55 |
| CHEMBL373587 | — | — | 1 | 5.32 |
| CHEMBL374632 | — | — | 1 | 5.03 |
| CHEMBL378647 | — | — | 1 | 4.75 |
| CHEMBL213746 | — | — | 1 | 4.69 |
| CHEMBL213488 | — | — | 1 | 4.51 |
| CHEMBL213438 | — | — | 1 | 4.42 |
| CHEMBL212242 | — | — | 1 | 4.38 |
| CHEMBL214947 | — | — | 1 | - |
| CHEMBL212070 | — | — | 1 | - |
| CHEMBL213022 | — | — | 1 | - |
| CHEMBL212037 | — | — | 1 | - |
| CHEMBL379350 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL210065 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL373587 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL374632 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL378647 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL213746 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL213488 | — | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL213438 | — | IC50 | = | 37700.0 | nM | 4.42 |
| CHEMBL212242 | — | IC50 | = | 41400.0 | nM | 4.38 |
| CHEMBL214947 | — | IC50 | > | 70000.0 | nM | - |
| CHEMBL212070 | — | IC50 | > | 70000.0 | nM | - |
| CHEMBL213022 | — | IC50 | > | 70000.0 | nM | - |
| CHEMBL212037 | — | IC50 | > | 70000.0 | nM | - |
| CHEMBL379350 | — | IC50 | > | 70000.0 | nM | - |