Assay Detail
Binding
CHEMBL855992
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Inhibition of human 11beta-HSD2
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
11-beta-hydroxysteroid dehydrogenase type 2 (CHEMBL3746) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.25 | 4.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386315 | — | — | 1 | 4.80 |
| CHEMBL3085038 | — | — | 1 | 4.16 |
| CHEMBL218247 | — | — | 1 | 4.05 |
| CHEMBL219606 | — | — | 1 | 4.00 |
| CHEMBL384426 | — | — | 1 | - |
| CHEMBL219403 | — | — | 2 | - |
| CHEMBL216783 | — | — | 1 | - |
| CHEMBL375743 | — | — | 1 | - |
| CHEMBL384692 | — | — | 1 | - |
| CHEMBL374409 | — | — | 1 | - |
| CHEMBL218246 | — | — | 1 | - |
| CHEMBL219448 | — | — | 1 | - |
| CHEMBL219295 | — | — | 1 | - |
| CHEMBL387010 | — | — | 1 | - |
| CHEMBL386947 | — | — | 1 | - |
| CHEMBL387424 | — | — | 1 | - |
| CHEMBL376272 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386315 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3085038 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL218247 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL219606 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL384426 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL219403 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL216783 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL375743 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL384692 | — | IC50 | - | — | - | |
| CHEMBL374409 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL376272 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL218246 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL219295 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL387010 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL219403 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL386947 | — | IC50 | - | — | - | |
| CHEMBL387424 | — | IC50 | - | — | - | |
| CHEMBL219448 | — | IC50 | > | 100000.0 | nM | - |