Assay Detail
Functional
CHEMBL856011
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cell cycle arrest in KB/HeLa cells by accumulation at G2/M phase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.57 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 8.62 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.85 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.31 |
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 7.04 |
| CHEMBL219102 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL107 | COLCHICINE | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL428647 | PACLITAXEL | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL9514 | NOCODAZOLE | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL219102 | — | EC50 | = | 98.0 | nM | 7.01 |