Assay Detail
Functional
CHEMBL856057
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CCRF-CEM (human leukemia) cell growth in vitro.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.04 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL172085 | — | — | 1 | 5.24 |
| CHEMBL170527 | — | — | 1 | 4.83 |
| CHEMBL177208 | — | — | 1 | - |
| CHEMBL171418 | — | — | 1 | - |
| CHEMBL170767 | — | — | 1 | - |
| CHEMBL172033 | — | — | 1 | - |
| CHEMBL171641 | — | — | 1 | - |
| CHEMBL301423 | — | — | 1 | - |
| CHEMBL57333 | — | — | 1 | - |
| CHEMBL173683 | — | — | 1 | - |
| CHEMBL367651 | — | — | 1 | - |
| CHEMBL353951 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL172085 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL170527 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL177208 | — | IC50 | > | 5600.0 | nM | - |
| CHEMBL171418 | — | IC50 | > | 7700.0 | nM | - |
| CHEMBL170767 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL172033 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL171641 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL301423 | — | IC50 | > | 4300.0 | nM | - |
| CHEMBL57333 | — | IC50 | > | 10700.0 | nM | - |
| CHEMBL173683 | — | IC50 | > | 26000.0 | nM | - |
| CHEMBL367651 | — | IC50 | > | 4800.0 | nM | - |
| CHEMBL353951 | — | IC50 | > | 6700.0 | nM | - |