Assay Detail
Functional
CHEMBL856074
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In vitro growth inhibitory activity in the human CCRF-CEM leukemia cell line.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 9.10 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL536102 | — | — | 1 | 10.89 |
| CHEMBL99640 | — | — | 1 | 10.70 |
| CHEMBL555858 | — | — | 1 | 10.68 |
| CHEMBL316640 | CRYPTOPHYCIN 52 | — | 1 | 10.66 |
| CHEMBL406057 | — | — | 1 | 10.43 |
| CHEMBL553055 | — | — | 1 | 10.40 |
| CHEMBL327295 | — | — | 1 | 10.30 |
| CHEMBL263425 | — | — | 1 | 10.30 |
| CHEMBL536563 | — | — | 1 | 10.04 |
| CHEMBL102236 | — | — | 1 | 9.82 |
| CHEMBL329990 | — | — | 1 | 9.55 |
| CHEMBL99856 | — | — | 1 | 9.54 |
| CHEMBL318838 | — | — | 1 | 9.52 |
| CHEMBL103389 | — | — | 1 | 9.22 |
| CHEMBL430656 | — | — | 1 | 9.10 |
| CHEMBL100603 | — | — | 1 | 9.10 |
| CHEMBL557992 | — | — | 1 | 9.10 |
| CHEMBL318975 | — | — | 1 | 8.70 |
| CHEMBL103264 | — | — | 1 | 8.40 |
| CHEMBL100279 | — | — | 1 | 7.92 |
| CHEMBL86762 | — | — | 1 | 7.85 |
| CHEMBL103638 | — | — | 1 | 7.60 |
| CHEMBL102573 | — | — | 1 | 7.16 |
| CHEMBL104949 | — | — | 1 | 7.00 |
| CHEMBL102700 | — | — | 1 | 6.36 |
| CHEMBL327294 | — | — | 1 | 6.34 |
| CHEMBL544103 | — | — | 1 | - |
| CHEMBL319668 | — | — | 1 | - |
| CHEMBL317978 | — | — | 1 | - |
| CHEMBL554321 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL536102 | — | IC50 | = | 0.013 | nM | 10.89 |
| CHEMBL99640 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL555858 | — | IC50 | = | 0.021 | nM | 10.68 |
| CHEMBL316640 | CRYPTOPHYCIN 52 | IC50 | = | 0.022 | nM | 10.66 |
| CHEMBL406057 | — | IC50 | = | 0.037 | nM | 10.43 |
| CHEMBL553055 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL327295 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL263425 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL536563 | — | IC50 | = | 0.092 | nM | 10.04 |
| CHEMBL102236 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL329990 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL99856 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL318838 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL103389 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL100603 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL557992 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL430656 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL318975 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL103264 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL100279 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL86762 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL103638 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL102573 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL104949 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL102700 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL327294 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL544103 | — | IC50 | = | 0.005 | nM | - |
| CHEMBL319668 | — | IC50 | = | 0.0055 | nM | - |
| CHEMBL317978 | — | IC50 | = | 0.004 | nM | - |
| CHEMBL554321 | — | IC50 | = | 0.004 | nM | - |
| CHEMBL318549 | — | IC50 | = | 0.003 | nM | - |
| CHEMBL101334 | — | IC50 | = | 0.001 | nM | - |