Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL856169

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration to factor Xa
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis and structure-activity relationships of benzoxazinone-based factor Xa inhibitors.
Huang W, Zhang P, Zuckett JF, Wang L, Woolfrey J, Song Y, Jia ZJ, Clizbe LA, Su T, Tran K, Huang B, Wong P, Sinha U, Park G, Reed A, Malinowski J, Hollenbach SJ, Scarborough RM, Zhu BY.
Bioorg Med Chem Lett (2003) 13 : 561 -566
PubMed 12565972 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 30 7.30 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL153134 1 9.10
CHEMBL20240 YM-60828 1 8.70
CHEMBL152049 1 8.70
CHEMBL152599 1 8.70
CHEMBL152631 1 8.52
CHEMBL423959 1 8.52
CHEMBL152514 1 8.40
CHEMBL153640 1 8.22
CHEMBL356153 1 8.22
CHEMBL153713 1 8.22
CHEMBL152069 1 8.22
CHEMBL151967 1 8.15
CHEMBL152661 1 8.15
CHEMBL152881 1 8.05
CHEMBL345763 1 7.85
CHEMBL152149 1 7.60
CHEMBL345785 1 7.51
CHEMBL155447 1 7.28
CHEMBL153317 1 6.82
CHEMBL152245 1 6.72
CHEMBL356416 1 6.30
CHEMBL152490 1 6.03
CHEMBL356879 1 5.98
CHEMBL153482 1 5.80
CHEMBL152516 1 5.41
CHEMBL357976 1 5.39
CHEMBL152344 1 5.16
CHEMBL152018 1 5.16
CHEMBL152792 1 4.83
CHEMBL151189 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL153134 IC50 = 0.8 nM 9.10
CHEMBL20240 YM-60828 IC50 = 2.0 nM 8.70
CHEMBL152049 IC50 = 2.0 nM 8.70
CHEMBL152599 IC50 = 2.0 nM 8.70
CHEMBL152631 IC50 = 3.0 nM 8.52
CHEMBL423959 IC50 = 3.0 nM 8.52
CHEMBL152514 IC50 = 4.0 nM 8.40
CHEMBL153640 IC50 = 6.0 nM 8.22
CHEMBL356153 IC50 = 6.0 nM 8.22
CHEMBL153713 IC50 = 6.0 nM 8.22
CHEMBL152069 IC50 = 6.0 nM 8.22
CHEMBL151967 IC50 = 7.0 nM 8.15
CHEMBL152661 IC50 = 7.0 nM 8.15
CHEMBL152881 IC50 = 9.0 nM 8.05
CHEMBL345763 IC50 = 14.0 nM 7.85
CHEMBL152149 IC50 = 25.0 nM 7.60
CHEMBL345785 IC50 = 31.0 nM 7.51
CHEMBL155447 IC50 = 52.0 nM 7.28
CHEMBL153317 IC50 = 153.0 nM 6.82
CHEMBL152245 IC50 = 191.0 nM 6.72
CHEMBL356416 IC50 = 500.0 nM 6.30
CHEMBL152490 IC50 = 934.0 nM 6.03
CHEMBL356879 IC50 = 1050.0 nM 5.98
CHEMBL153482 IC50 = 1570.0 nM 5.80
CHEMBL152516 IC50 = 3933.0 nM 5.41
CHEMBL357976 IC50 = 4060.0 nM 5.39
CHEMBL152344 IC50 = 7000.0 nM 5.16
CHEMBL152018 IC50 = 6920.0 nM 5.16
CHEMBL152792 IC50 = 14900.0 nM 4.83
CHEMBL151189 IC50 > 10000.0 nM -