Assay Detail
Binding
CHEMBL856170
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]muscimol binding to GABA A receptor with compound alone at 10 e-4 M
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.36 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9 | NORFLOXACIN | 4.0 | 1 | 4.89 |
| CHEMBL15549 | — | — | 1 | 4.19 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 4.00 |
| CHEMBL29929 | — | — | 1 | - |
| CHEMBL28858 | — | — | 1 | - |
| CHEMBL26154 | — | — | 1 | - |
| CHEMBL4 | OFLOXACIN | 4.0 | 1 | - |
| CHEMBL27345 | — | — | 1 | - |
| CHEMBL29572 | — | — | 1 | - |
| CHEMBL418569 | — | — | 1 | - |
| CHEMBL26523 | — | — | 1 | - |
| CHEMBL282127 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9 | NORFLOXACIN | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL15549 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL29929 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL28858 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL26154 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4 | OFLOXACIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL27345 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL29572 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL418569 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL26523 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL282127 | — | IC50 | > | 100000.0 | nM | - |