Assay Detail

CHEMBL856187

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Functional

Effect on vinblastine IC50 against MDR human carcinoma HCT116/VM46 cell line at a dose of 1 uM concentration

ChEMBL ↗

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Target

HCT-116 (CHEMBL394) ↗

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Primary target HCT-116

CHEMBL394

Anchored from Assay target.

Protein identity HCT-116

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HCT-116
Confidence	1 — Organism
Curated By	Intermediate

Target

HCT-116 (CHEMBL394) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Multidrug resistance reversal activity of key ningalin analogues.

Soenen DR, Hwang I, Hedrick MP, Boger DL.
Bioorg Med Chem Lett (2003) 13 : 1777 -1781
PubMed 12729663 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.40	8.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL6966	VERAPAMIL	4.0	1	8.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL6966	VERAPAMIL	IC50	=	4.0	nM	8.40