Assay Detail
Functional
CHEMBL856216
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration of compound required to inhibit 50% of viral replication of Rauscher-Murine leukemia virus
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rauscher murine leukemia virus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Rauscher murine leukemia virus (CHEMBL613748) ↗| Type | ORGANISM |
| Organism | Rauscher murine leukemia virus |
Publication
Synthesis and antiviral activity of several 2,5'-anhydro analogues of 3'-azido-3'-deoxythymidine, 3'-azido-2',3'-dideoxyuridine, 3'-azido-2',3'-dideoxy-5-halouridines, and 3'-deoxythymidine against human immunodeficiency virus and Rauscher-murine leukemia virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.18 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.64 |
| CHEMBL1791030 | — | — | 1 | 6.68 |
| CHEMBL1791024 | — | — | 1 | 6.64 |
| CHEMBL1794993 | — | — | 1 | 6.57 |
| CHEMBL1794991 | — | — | 1 | 4.79 |
| CHEMBL1794994 | — | — | 1 | 4.75 |
| CHEMBL591804 | NAVURIDINE | 2.0 | 1 | - |
| CHEMBL443742 | — | — | 1 | - |
| CHEMBL444314 | — | — | 1 | - |
| CHEMBL1794990 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1791030 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1791024 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1794993 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1794991 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL1794994 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL591804 | NAVURIDINE | IC50 | = | 138000.0 | nM | - |
| CHEMBL443742 | — | IC50 | > | 480000.0 | nM | - |
| CHEMBL444314 | — | IC50 | > | 442000.0 | nM | - |
| CHEMBL1794990 | — | IC50 | = | 114000.0 | nM | - |