Assay Detail
Functional
CHEMBL856267
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against human colorectal adenocarcinoma Caco-2 cells in the presence of vinblastine sulfate salt
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Caco-2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potential antitumor agents: flavones and their derivatives from Linaria reflexa Desf.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.96 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445978 | PECTOLINARIN | — | 1 | 5.21 |
| CHEMBL197035 | LINARIIN | — | 1 | 5.10 |
| CHEMBL197088 | ISOLINARIIN A | — | 1 | 5.07 |
| CHEMBL194462 | — | — | 1 | 4.90 |
| CHEMBL196252 | — | — | 1 | 4.86 |
| CHEMBL196125 | PERACETYLPECTOLINARIN | — | 1 | 4.63 |
| CHEMBL194463 | — | — | 1 | - |
| CHEMBL364464 | ANTIRRHINOSIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445978 | PECTOLINARIN | IC50 | = | 6180.0 | nM | 5.21 |
| CHEMBL197035 | LINARIIN | IC50 | = | 8010.0 | nM | 5.10 |
| CHEMBL197088 | ISOLINARIIN A | IC50 | = | 8540.0 | nM | 5.07 |
| CHEMBL194462 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL196252 | — | IC50 | = | 13970.0 | nM | 4.86 |
| CHEMBL196125 | PERACETYLPECTOLINARIN | IC50 | = | 23410.0 | nM | 4.63 |
| CHEMBL194463 | — | IC50 | > | 151500.0 | nM | - |
| CHEMBL364464 | ANTIRRHINOSIDE | IC50 | > | 138100.0 | nM | - |