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Compound Detail

CHEMBL197035

LINARIIN
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COc1ccc(-c2cc(=O)c3c(O)c(O)c(O[C@@H]4OC(CO[C@@H]5OC(C)[C@H](OC(C)=O)[C@H](O)C5O)[C@@H](O)C(O)[C@@H]4O)cc3o2)cc1

Basic Information

ChEMBL ID CHEMBL197035
Name LINARIIN
Phase Preclinical
Structure Type MOL
InChI Key HUSAJBGAYWEOJX-OICJVVKOSA-N
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

650.6
MW (Da)
-0.52
ALogP
16
HBA
7
HBD
244.3
PSA (Ų)
0.12
QED
3
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H34O16
MW 650.59
Aromatic Rings 3
Heavy Atoms 46
NP-Likeness 1.93

Activity Summary

IC50 5 meas. best 5.29

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
COR-L23
CHEMBL613854
IC50 5.29 5.29 5170.0 1
Caco-2
CHEMBL614058
IC50 5.1 5.1 8010.0 1
ACHN
CHEMBL614519
IC50 4.95 4.95 11250.0 1
NON-PROTEIN TARGET
CHEMBL3879801
IC50 4.9 4.9 12600.0 1
HepG2
CHEMBL395
IC50 4.63 4.63 23210.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine