Assay Detail
Functional
CHEMBL856258
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against renal adenocarcinoma cell line (ACHN) in the presence of taxol
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ACHN |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potential antitumor agents: flavones and their derivatives from Linaria reflexa Desf.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.79 | 4.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197035 | LINARIIN | — | 1 | 4.95 |
| CHEMBL197088 | ISOLINARIIN A | — | 1 | 4.87 |
| CHEMBL78010 | PECTOLINARIGENIN | — | 1 | 4.82 |
| CHEMBL194462 | — | — | 1 | 4.78 |
| CHEMBL196252 | — | — | 1 | 4.77 |
| CHEMBL445978 | PECTOLINARIN | — | 1 | 4.76 |
| CHEMBL196125 | PERACETYLPECTOLINARIN | — | 1 | 4.60 |
| CHEMBL194463 | — | — | 1 | - |
| CHEMBL364464 | ANTIRRHINOSIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197035 | LINARIIN | IC50 | = | 11250.0 | nM | 4.95 |
| CHEMBL197088 | ISOLINARIIN A | IC50 | = | 13650.0 | nM | 4.87 |
| CHEMBL78010 | PECTOLINARIGENIN | IC50 | = | 15230.0 | nM | 4.82 |
| CHEMBL194462 | — | IC50 | = | 16540.0 | nM | 4.78 |
| CHEMBL196252 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL445978 | PECTOLINARIN | IC50 | = | 17220.0 | nM | 4.76 |
| CHEMBL196125 | PERACETYLPECTOLINARIN | IC50 | = | 25230.0 | nM | 4.60 |
| CHEMBL194463 | — | IC50 | > | 151500.0 | nM | - |
| CHEMBL364464 | ANTIRRHINOSIDE | IC50 | > | 138100.0 | nM | - |