Assay Detail
Binding
CHEMBL856334
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Inhibition of DPP2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and dipeptidyl peptidase inhibition of N-(4-substituted-2,4-diaminobutanoyl)piperidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.14 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98869 | — | — | 1 | 9.66 |
| CHEMBL215299 | — | — | 1 | 9.21 |
| CHEMBL215244 | — | — | 1 | 8.47 |
| CHEMBL214630 | — | — | 1 | 8.42 |
| CHEMBL373665 | — | — | 1 | 7.72 |
| CHEMBL213514 | — | — | 1 | 7.33 |
| CHEMBL215824 | — | — | 1 | 7.24 |
| CHEMBL214580 | — | — | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98869 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL215299 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL215244 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL214630 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL373665 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL213514 | — | IC50 | = | 46.5 | nM | 7.33 |
| CHEMBL215824 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL214580 | — | IC50 | = | 84.0 | nM | 7.08 |