Assay Detail
Binding
CHEMBL856400
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.68 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL387187 | — | — | 1 | 7.68 |
| CHEMBL383899 | ANILINOPYRIMIDINE1 | — | 1 | - |
| CHEMBL216260 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL387187 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL383899 | ANILINOPYRIMIDINE1 | IC50 | > | 10000.0 | nM | - |
| CHEMBL216260 | — | IC50 | > | 10000.0 | nM | - |