Assay Detail
Binding
CHEMBL856404
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Inhibition of human recombinant Aurora B
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 8.50 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215275 | — | — | 1 | 9.00 |
| CHEMBL386253 | — | — | 1 | 9.00 |
| CHEMBL424899 | — | — | 1 | 9.00 |
| CHEMBL385049 | — | — | 1 | 9.00 |
| CHEMBL217804 | — | — | 1 | 8.70 |
| CHEMBL405120 | — | — | 1 | 6.29 |
| CHEMBL215203 | — | — | 1 | - |
| CHEMBL215495 | — | — | 1 | - |
| CHEMBL215152 | DEFOSBARASERTIB | 2.0 | 1 | - |
| CHEMBL215022 | — | — | 1 | - |
| CHEMBL214637 | — | — | 1 | - |
| CHEMBL215322 | — | — | 1 | - |
| CHEMBL216053 | — | — | 1 | - |
| CHEMBL214849 | — | — | 1 | - |
| CHEMBL214848 | — | — | 1 | - |
| CHEMBL214940 | — | — | 1 | - |
| CHEMBL214601 | — | — | 1 | - |
| CHEMBL386310 | — | — | 1 | - |
| CHEMBL214842 | — | — | 1 | - |
| CHEMBL384054 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215275 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL386253 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL424899 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL385049 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL217804 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL405120 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL215203 | — | Ki | < | 1.0 | nM | - |
| CHEMBL215495 | — | Ki | < | 1.0 | nM | - |
| CHEMBL215152 | DEFOSBARASERTIB | Ki | < | 1.0 | nM | - |
| CHEMBL215022 | — | Ki | < | 1.0 | nM | - |
| CHEMBL214637 | — | Ki | < | 1.0 | nM | - |
| CHEMBL215322 | — | Ki | < | 1.0 | nM | - |
| CHEMBL216053 | — | Ki | < | 1.0 | nM | - |
| CHEMBL214849 | — | Ki | < | 1.0 | nM | - |
| CHEMBL214848 | — | Ki | < | 1.0 | nM | - |
| CHEMBL214940 | — | Ki | < | 1.0 | nM | - |
| CHEMBL214601 | — | Ki | < | 1.0 | nM | - |
| CHEMBL386310 | — | Ki | < | 1.0 | nM | - |
| CHEMBL214842 | — | Ki | < | 1.0 | nM | - |
| CHEMBL384054 | — | Ki | < | 1.0 | nM | - |