Assay Detail
ADMET
CHEMBL856410
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P450 isoforms 3A4
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.26 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214849 | — | — | 1 | 5.47 |
| CHEMBL215022 | — | — | 1 | 5.19 |
| CHEMBL385049 | — | — | 1 | 5.12 |
| CHEMBL215152 | DEFOSBARASERTIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214849 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL215022 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL385049 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL215152 | DEFOSBARASERTIB | IC50 | > | 10000.0 | nM | - |