Assay Detail
Functional
CHEMBL856445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect on production of LTB4 in human polymorphonuclear (HPMN) leukocytes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.65 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16596 | QUIFLAPON | 2.0 | 1 | 8.52 |
| CHEMBL275887 | — | — | 1 | 8.10 |
| CHEMBL16334 | — | — | 1 | 8.00 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16596 | QUIFLAPON | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL275887 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL16334 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL93 | ZILEUTON | IC50 | = | 1060.0 | nM | 5.97 |