Assay Detail
Binding
CHEMBL856493
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Inhibition of c-RAF1/MEK1/ERK2 signalling pathway by SPA
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Aza-stilbenes as potent and selective c-RAF inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.58 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218791 | — | — | 1 | 8.40 |
| CHEMBL220019 | — | — | 1 | 8.20 |
| CHEMBL219870 | — | — | 1 | 8.10 |
| CHEMBL218932 | GW432441X | — | 1 | 8.00 |
| CHEMBL374410 | — | — | 1 | 7.90 |
| CHEMBL219453 | — | — | 1 | 7.50 |
| CHEMBL219745 | — | — | 1 | 7.40 |
| CHEMBL219756 | — | — | 1 | 7.10 |
| CHEMBL219591 | — | — | 1 | 7.00 |
| CHEMBL374680 | — | — | 1 | 7.00 |
| CHEMBL218088 | GW435821X | — | 1 | 6.80 |
| CHEMBL218859 | GW445012X | — | 1 | 6.60 |
| CHEMBL218858 | — | — | 1 | 6.60 |
| CHEMBL263796 | GW445014X | — | 1 | 6.60 |
| CHEMBL441547 | — | — | 1 | 6.50 |
| CHEMBL216668 | — | — | 1 | 6.40 |
| CHEMBL373576 | — | — | 1 | 6.20 |
| CHEMBL374647 | — | — | 1 | 6.20 |
| CHEMBL220243 | GW406731X | — | 1 | 6.20 |
| CHEMBL219507 | — | — | 1 | 6.10 |
| CHEMBL385257 | — | — | 1 | 6.10 |
| CHEMBL219148 | — | — | 1 | 6.00 |
| CHEMBL218970 | GW445017X | — | 1 | 5.70 |
| CHEMBL218969 | GW445015X | — | 1 | 5.50 |
| CHEMBL374060 | GW439255X | — | 1 | 5.40 |
| CHEMBL219797 | — | — | 1 | 5.10 |
| CHEMBL220244 | GW427984X | — | 1 | 5.10 |
| CHEMBL385426 | GW450241X | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218791 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL220019 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL219870 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL218932 | GW432441X | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL374410 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL219453 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL219745 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL219756 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL219591 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL374680 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL218088 | GW435821X | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL218859 | GW445012X | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL218858 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL263796 | GW445014X | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL441547 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL216668 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL373576 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL374647 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL220243 | GW406731X | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL219507 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL385257 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL219148 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL218970 | GW445017X | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL218969 | GW445015X | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL374060 | GW439255X | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL219797 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL220244 | GW427984X | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL385426 | GW450241X | IC50 | = | 25118.86 | nM | 4.60 |