Assay Detail
Binding
CHEMBL856530
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Inhibition of tubulin polymerization in porcine brain
32
Total Activities
32
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.91 | 6.89 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378544 | VINBLASTINE SULFATE | 4.0 | 1 | 6.89 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 6.46 |
| CHEMBL219102 | — | — | 1 | 6.42 |
| CHEMBL219439 | — | — | 1 | 6.30 |
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 6.12 |
| CHEMBL376511 | — | — | 1 | 6.11 |
| CHEMBL218923 | — | — | 1 | 6.06 |
| CHEMBL218824 | — | — | 1 | 5.87 |
| CHEMBL441863 | — | — | 1 | 5.85 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.85 |
| CHEMBL437521 | — | — | 1 | 5.82 |
| CHEMBL219353 | — | — | 1 | 5.55 |
| CHEMBL376853 | — | — | 1 | 5.48 |
| CHEMBL218921 | — | — | 1 | 5.40 |
| CHEMBL219064 | — | — | 1 | 5.21 |
| CHEMBL219100 | — | — | 1 | 5.13 |
| CHEMBL373414 | — | — | 1 | - |
| CHEMBL374139 | — | — | 1 | - |
| CHEMBL218866 | — | — | 1 | - |
| CHEMBL216099 | — | — | 1 | - |
| CHEMBL425978 | — | — | 1 | - |
| CHEMBL218867 | — | — | 1 | - |
| CHEMBL374109 | — | — | 1 | - |
| CHEMBL375624 | — | — | 1 | - |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
| CHEMBL219180 | — | — | 1 | - |
| CHEMBL374924 | — | — | 1 | - |
| CHEMBL218920 | — | — | 1 | - |
| CHEMBL219525 | — | — | 1 | - |
| CHEMBL374466 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378544 | VINBLASTINE SULFATE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL61 | PODOFILOX | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL219102 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL219439 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL376511 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL218923 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL218824 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL441863 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL437521 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL219353 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL376853 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL218921 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL219064 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL219100 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL427056 | — | IC50 | - | — | - | |
| CHEMBL216150 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL374466 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL219525 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL218920 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL374924 | — | IC50 | - | — | - | |
| CHEMBL219180 | — | IC50 | - | — | - | |
| CHEMBL53463 | DOXORUBICIN | IC50 | - | — | - | |
| CHEMBL375624 | — | IC50 | - | — | - | |
| CHEMBL374109 | — | IC50 | - | — | - | |
| CHEMBL218867 | — | Activity | - | — | - | |
| CHEMBL425978 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL216099 | — | IC50 | - | — | - | |
| CHEMBL218866 | — | IC50 | - | — | - | |
| CHEMBL374139 | — | IC50 | - | — | - | |
| CHEMBL373414 | — | IC50 | - | — | - |