Assay Detail
Functional
CHEMBL856671
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Inhibition of Escherichia coli gyrase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Escherichia coli |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
3-aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organisms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.48 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 6.70 |
| CHEMBL383917 | — | — | 1 | 6.70 |
| CHEMBL31 | GATIFLOXACIN | 4.0 | 1 | 6.30 |
| CHEMBL217592 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL383917 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL31 | GATIFLOXACIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL217592 | — | IC50 | = | 600.0 | nM | 6.22 |