Assay Detail
Binding
CHEMBL856815
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Platelet-derived growth factor receptor alpha
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor alpha (CHEMBL2007) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Molecular modeling of wild-type and D816V c-Kit inhibition based on ATP-competitive binding of ellipticine derivatives to tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.03 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26559 | — | — | 1 | 6.22 |
| CHEMBL16699 | ELLIPTINIUM | 2.0 | 1 | 6.16 |
| CHEMBL55137 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26559 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL16699 | ELLIPTINIUM | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL55137 | — | IC50 | = | 2000.0 | nM | 5.70 |